The Role of Lymphatics in Cancer as Assessed by Near-Infrared Fluorescence Imaging
Identifieur interne : 004A78 ( Main/Exploration ); précédent : 004A77; suivant : 004A79The Role of Lymphatics in Cancer as Assessed by Near-Infrared Fluorescence Imaging
Auteurs : John C. Rasmussen [États-Unis] ; Sunkuk Kwon [États-Unis] ; Eva M. Sevick-Muraca [États-Unis] ; Janice N. Cormier [États-Unis]Source :
- Annals of Biomedical Engineering [ 0090-6964 ] ; 2011.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Mélanome, Vaisseaux lymphatiques.
- diagnostic : Mélanome.
- instrumentation : Animaux, Diagnostic par imagerie, Fluorescence, Humains.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Melanoma.
- instrumentation : Diagnostic Imaging.
- methods : Diagnostic Imaging.
- pathology : Lymphatic Vessels, Melanoma.
- Animals, Fluorescence, Humans.
Abstract
The lymphatic system is the secondary circulatory system responsible for fluid homeostasis and protein transport in the body. In addition, because the lymphatic system provides a primary pathway for cancer metastasis, lymph node involvement is routinely used as a determinant in cancer staging. Despite their importance, the lymphatics remain poorly understood, in part because of the historic lack of imaging modalities with sufficient spatial and/or temporal resolution to visualize the fine lymphatic structure and subtle contractile function. In recent years, near-infrared fluorescence (NIRF) imaging has emerged as a new imaging modality to non-invasively visualize the lymphatics and assess contractile lymphatic function in humans following administration of microdose amounts of a NIRF contrast agent. In this contribution, we first review NIRF imaging and its clinical application in sentinel lymph node mapping, intraoperative guidance, and assessing the architecture and contractile function of the lymphatics in health and in cancer-related lymphedema. We then present recent NIRF lymphatic imaging for non-invasive assessment of lymphatics both in preclinical melanoma models and in human subjects with melanoma.
Url:
DOI: 10.1007/s10439-011-0476-1
PubMed: 22139396
PubMed Central: 3288459
Affiliations:
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Le document en format XML
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Rasmussen</name><affiliation wicri:level="1"><nlm:aff id="A1">Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, 1825 Pressler St, SRB 330F, Houston, TX 77030, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, 1825 Pressler St, SRB 330F, Houston, TX 77030</wicri:regionArea><wicri:noRegion>TX 77030</wicri:noRegion></affiliation></author><author><name sortKey="Kwon, Sunkuk" sort="Kwon, Sunkuk" uniqKey="Kwon S" first="Sunkuk" last="Kwon">Sunkuk Kwon</name><affiliation wicri:level="1"><nlm:aff id="A1">Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, 1825 Pressler St, SRB 330F, Houston, TX 77030, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, 1825 Pressler St, SRB 330F, Houston, TX 77030</wicri:regionArea><wicri:noRegion>TX 77030</wicri:noRegion></affiliation></author><author><name sortKey="Sevick Muraca, Eva M" sort="Sevick Muraca, Eva M" uniqKey="Sevick Muraca E" first="Eva M." last="Sevick-Muraca">Eva M. 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Cormier</name><affiliation wicri:level="1"><nlm:aff id="A2">The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The University of Texas M.D. Anderson Cancer Center, Houston, TX</wicri:regionArea><wicri:noRegion>TX</wicri:noRegion></affiliation></author></analytic><series><title level="j">Annals of Biomedical Engineering</title><idno type="ISSN">0090-6964</idno><idno type="eISSN">1521-6047</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Diagnostic Imaging (instrumentation)</term><term>Diagnostic Imaging (methods)</term><term>Fluorescence</term><term>Humans</term><term>Lymphatic Vessels (pathology)</term><term>Melanoma (diagnosis)</term><term>Melanoma (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Diagnostic par imagerie ()</term><term>Diagnostic par imagerie (instrumentation)</term><term>Fluorescence</term><term>Humains</term><term>Mélanome (anatomopathologie)</term><term>Mélanome (diagnostic)</term><term>Vaisseaux lymphatiques (anatomopathologie)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Mélanome</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Melanoma</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Mélanome</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Diagnostic Imaging</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Diagnostic Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphatic Vessels</term><term>Melanoma</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Fluorescence</term><term>Humans</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="fr"><term>Animaux</term><term>Diagnostic par imagerie</term><term>Fluorescence</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The lymphatic system is the secondary circulatory system responsible for fluid homeostasis and protein transport in the body. In addition, because the lymphatic system provides a primary pathway for cancer metastasis, lymph node involvement is routinely used as a determinant in cancer staging. Despite their importance, the lymphatics remain poorly understood, in part because of the historic lack of imaging modalities with sufficient spatial and/or temporal resolution to visualize the fine lymphatic structure and subtle contractile function. In recent years, near-infrared fluorescence (NIRF) imaging has emerged as a new imaging modality to non-invasively visualize the lymphatics and assess contractile lymphatic function in humans following administration of microdose amounts of a NIRF contrast agent. In this contribution, we first review NIRF imaging and its clinical application in sentinel lymph node mapping, intraoperative guidance, and assessing the architecture and contractile function of the lymphatics in health and in cancer-related lymphedema. We then present recent NIRF lymphatic imaging for non-invasive assessment of lymphatics both in preclinical melanoma models and in human subjects with melanoma.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Rasmussen, John C" sort="Rasmussen, John C" uniqKey="Rasmussen J" first="John C." last="Rasmussen">John C. Rasmussen</name></noRegion><name sortKey="Cormier, Janice N" sort="Cormier, Janice N" uniqKey="Cormier J" first="Janice N." last="Cormier">Janice N. Cormier</name><name sortKey="Kwon, Sunkuk" sort="Kwon, Sunkuk" uniqKey="Kwon S" first="Sunkuk" last="Kwon">Sunkuk Kwon</name><name sortKey="Sevick Muraca, Eva M" sort="Sevick Muraca, Eva M" uniqKey="Sevick Muraca E" first="Eva M." last="Sevick-Muraca">Eva M. Sevick-Muraca</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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